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A named entity — readable, and safe in any HTML document without declaring a charset.

®

The numeric form works everywhere a named one does, and exists for every character.

\00AE

For a content property in a ::before or ::after rule. No semicolon, and mind the trailing space.

\u00AE

Valid in a JavaScript or JSON string literal, so it survives files and pipelines that are not UTF-8 clean.

\u00AE

The escape for a Python string literal.

%C2%AE

Percent-encoded UTF-8, for a query string or a path segment.

C2 AE

2 bytes on the wire. Seeing these as separate garbled characters means something decoded them as single-byte text.